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LAX1 and lack
(2 results)?
Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren's syndrome highlight T cell-initiated autoimmunity.
Ann Rheum Dis. 2020 Feb;79(2):268-275. doi: 10.1136/annrheumdis-2019-215533. Epub 2019 Dec 17.
Ann Rheum Dis. 2020.
PMID: 31848144
Among this gene set, regulation of T cell activation (p=4.0610(-7)) and T cell receptor (TCR) signalling pathway (p=1.7310(-6)) were particularly concentrated, including PTPRC (CD45), LCK, LAT-SLP76 complex genes (THEMIS, LAT, ITK, TEC, TESPA1, PLCL1), DGKD, PRKD1, PAK2 an …
Among this gene set, regulation of T cell activation (p=4.0610(-7)) and T cell receptor (TCR) signalling pathway (p=1.7310(-6)) were particu …
The role of adaptor proteins in lymphocyte activation.
Togni M, Lindquist J, Gerber A, Kölsch U, Hamm-Baarke A, Kliche S, Schraven B.
Togni M, et al.
Mol Immunol. 2004 Jul;41(6-7):615-30. doi: 10.1016/j.molimm.2004.04.009.
Mol Immunol. 2004.
PMID: 15219999
Review.
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Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
Shapiro MJ, Nguyen CT, Aghajanian H, Zhang W, Shapiro VS.
Shapiro MJ, et al.
J Immunol. 2008 Nov 15;181(10):7055-61. doi: 10.4049/jimmunol.181.10.7055.
J Immunol. 2008.
PMID: 18981125
Free PMC article.
ALX-mediated LAX phosphorylation depends upon the ALX SH2 domain, which functions to recruit Lck to LAX. We also show that LAX, like ALX, can inhibit RE/AP reporter activation. ...
ALX-mediated LAX phosphorylation depends upon the ALX SH2 domain, which functions to recruit Lck to LAX. We also show that LAX, like …
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